The vast majority of spinal procedures involving bone morphogenetic protein (BMP) are off-label uses, researchers found.
From 2003 to 2007, the use of BMP more than quadrupled from 23,900 to 103,194 procedures, according to Kevin Ong, PhD, managing engineer at Exponent, an engineering and scientific consulting firm based in Menlo Park, Calif.
Although the FDA has approved BMP only for anterior lumbar interbody fusion, only 16.6% of the procedures in the study involved the approved use, researchers said.
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