Why good people get stuck in big Ortho companies

I get calls from good people who work in big Orthopedic companies and have decided to leave to join a startup.
It's not that easy.
You all know the frog in the frying pan story. Place a frog in a pan with water and start to heat. As the temperature rises, the frog’s system adjusts. When the water nears the boiling point the frog cannot adjust any longer, the legs don't work and he dies. Now the frog could have easily jumped out at any point, but the change was so GRADUAL that the frog did not notice.

What killed the frog?
Hint: It wasn’t the temperature. It was the frog's lack of judgement ...