If you've been in the ortho industry for any time, you know the big dogs like Stryker, Zimmer Biomet, and Depuy-Synthes have long held the fort.
But lately, two players—Globus Medical and Arthrex—are charging ahead, reshaping the US orthopedic scene with aggressive growth, smart strategies, and a laser focus on surgeon needs. We're talking spine supremacy, sports med innovation, and billions in revenue that's turning heads. Let's break it down on why these companies are starting to dominate, at least stateside, based on the latest 2025 data.
Globus Medical: From Spine Specialist to Musculoskeletal Powerhouse
Globus Medical, headquartered in Audubon, Pennsylvania, started as a spine-focused upstart in 2003 but has evolved into a full-spectrum orthopedic force through savvy mergers and organic expansion. Their big leap came in 2023 with the $3.1 billion all-stock merger with NuVasive, combining complementary portfolios in spine implants, robotics, and enabling tech. This deal didn't just bulk up their offerings—it catapulted them to the second-largest player in the $13 billion global spine market, right behind Medtronic. In the US, where spine procedures drive a huge chunk of ortho...
