Why Read?
Get a glimpse of the future of orthopedics, that's not AI, not imaging, not robotics, and not metal.
WARNING - this is a very technical article that bridges epigenetics, genomics, and immunology.
We have long focused on mechanical innovations such as advanced implants, robotic systems, and 3D-printed scaffolds.
However, consider this: what if the most significant advancement lies not in materials or machinery, but in the intricate cellular mechanisms governing gene expression—namely, epigenetics?
This emerging discipline elucidates how genes are activated or suppressed without altering the underlying DNA sequence, through mechanisms like DNA methylation and histone modifications that function akin to regulatory switches. In orthopedics, epigenetics is proving instrumental in unraveling complexities ranging from osteoarthritis (OA) progression to bone regeneration, implant integration, and cell-based therapies across the musculoskeletal (MSK) system, encompassing soft tissues such as tendons, ligaments, and muscles.
Through extensive review of recent PubMed Central publications, discussions on X (albeit limited on OA epigenetics), and professional dialogues, the po...
