The IPO window has opened up for orthopedics this year. Read more here - A detailed look at the positive Medline IPO and the opened door. In my mind, the five potential Ortho IPOs this year are:
1/ Advita Ortho (fka Exactech)
2/ EXALTA (merger of Tyber Medical, Intech and Resolve)
3/ Isto Biologics
4/ Highridge Medical
5/ OSSIO
For years, the orthopedic sector has relied on a steady pipeline of specialized IPOs to fuel growth and provide exit ramps for innovation. This is normal.
However, 2026 is not normal. A new phenomenon is emerging.
As "Mega IPOs"—the likes of which the market has never seen—descend upon the public markets, orthopedic players are starting to wonder if the atmospheric pressure is getting too low to breathe.
The Vacuum Effect of the "Big 3"
Take a look at the current projections for 2026. We aren't just facing a busy market; we are facing a gravitational anomaly. The projected "Big 3" IPOs—SpaceX, OpenAI, and Anthropic—are expected to command a combined exit value of $3.0 Trillion.
To put that in perspective, these three companies alone represent nearly 2.5x the total exit value of every US VC-backed IPO combined from 2015 to 2025.
The Reality Ch...
