Scouting

Faster, better orthopedic startup deal flow.

Book a quick chat: http://meetme.so/Tiger

Tiger Buford is an orthopedic insider who has a front row seat to 1,000 startups. He is providing a new service as a Venture Scout, bringing his deep expertise in healthcare technology and startup ecosystems to the forefront. Tiger is now offering a new scouting service that leverage his industry insights and network to identify promising, under-the-radar startups for VC firms.

His new scouting service aligns with the growing importance of VC scouts, who play a critical role in connecting founders with funding and fostering startup success. Tiger’s unique perspective and commitment to innovation position him as a key advocate for emerging companies, helping them secure the capital and connections needed to thrive in competitive markets.

Services via monthly retainer:

  1. Monthly curated report of 5 startups, detailing founders, funding, competitive edge, clinical solutions, and market potential.
  2. Real-time introductions to promising ortho startups that fit your investment criteria.

Faster, better orthopedic startup deal flow.

Book a quick chat: http://meetme.so/Tiger

My Story and Background

Back in the late 80s, I interviewed at Danek—a scrappy orthopedic startup with just 18 employees—and passed on joining. Big mistake: they became the spine giant. That missed boat fuels my hunt for under-the-radar orthopedic startups with huge investment potential.

Ever since then, I seek out and uncover under-the-radar orthopedic startups with huge investment potential. Here are my 7 criteria for spotting the next big thing in this $50B+ market—startups with the fundamentals to dominate, even without the spotlight.

Tiger has worked as a VP in three startups (one hit a funding wall, one hit a regulatory wall, and one was a home run). He has also recruited for ortho startups for nine years and counting. He also founded and curates a startup community called BoneChat.

He talks with ortho startups in all areas and geographies weekly (AI, sports med, trauma, extremities, nav, joints, robotics, and biologics) and vets them.

Sharing my 7 criteria for identifying under-the-radar orthopedic startups with serious investment potential. These are the startups that don’t yet have the spotlight but have the fundamentals to dominate.

Let’s dive into the 7 criteria.

1. A Leadership Team That’s Been There, Done That

The orthopedic device space is brutal—complex, regulated, and fiercely competitive. A startup’s leadership team needs to be battle-tested. I look for CEOs and founders who’ve navigated medtech before, ideally with a track record of successful exits or product launches. They don’t need to be household names, but they should know how to steer through FDA hurdles, surgeon adoption, and hospital purchasing committees.

Bonus points if they’ve got a co-founder with deep clinical expertise (think orthopedic surgeon or biomechanics PhD) to ground the tech in real-world needs. Red flag: A team of first-time founders with no medtech experience. Enthusiasm is great, but this isn’t a learn-as-you-go industry.

2. Solving a Clinical Need That Keeps Surgeons Up at Night

The best startups address a clear, urgent clinical problem—not a “nice-to-have.” I’m talking about innovations that solve pain points like reducing revision surgeries, improving patient outcomes in high-volume procedures (e.g., total joints), or tackling underserved niches (e.g., small joint reconstruction).

The clinical need should be so compelling that surgeons will champion the product without needing a hard sell. For example, a startup developing a novel implant for rotator cuff repair that cuts re-tear rates by 20%? That’s a game-changer. A newfangled screwdriver for spinal fusion? Probably not.

Key question: Does this product address a top-five problem in its target market? If not, it’s likely too niche to scale.

3. A Clear Path to Reimbursement

No matter how groundbreaking the tech, if it can’t get paid for, it’s dead on arrival. I prioritize startups with a clear reimbursement strategy—ideally leveraging existing CPT or DRG codes. A product that fits into established payment pathways (e.g., for joint replacements or fracture fixation) has a massive head start. If the startup is banking on new codes, they better have a bulletproof plan and relationships with payers or CMS.

Pro tip: Look for startups targeting procedures with high reimbursement rates or bundled payments where their device can demonstrably lower overall costs (e.g., by reducing OR time or hospital stays).

4. A Low-Risk Regulatory Pathway

Class III devices requiring premarket approval (PMA) are a slog—years of clinical trials, millions in costs, and no guarantee of approval. I gravitate toward startups pursuing 510(k) pathways, where they can leverage predicate devices and get to market faster with less capital. A well-executed 510(k) can mean commercialization in 12-18 months versus 3-5 years for a PMA.

That said, don’t sleep on startups with breakthrough device designation. The FDA’s program can fast-track innovative devices (even Class III) if they address life-threatening conditions or unmet needs, offering a rare blend of high impact and lower regulatory drag.

5. Defensible IP and a Moat

Orthopedics is crowded, with giants like Stryker and DePuy Synthes lurking. A startup needs strong intellectual property to fend off copycats and attract acquirers. I look for robust patents covering the core tech, not just incremental tweaks. Beyond IP, the startup should have a moat—maybe a proprietary manufacturing process, exclusive surgeon KOL relationships, or data-driven software that locks in users.

Example: A startup with a 3D-printed implant that’s 30% stronger and 20% cheaper to produce? That’s a moat. A me-too plate-and-screw system? Pass.

6. Scalable Market Opportunity

The orthopedic market is massive ($50B+ globally), but not every niche is worth chasing. I target startups addressing markets with at least $500M in addressable opportunity. Think high-volume procedures like knee replacements or spine fusions, or fast-growing segments like outpatient surgery or biologics. The startup should have a clear plan to capture 5-10% of that market within 5 years.

Underrated opportunity: Technologies enabling the shift to ambulatory surgery centers (ASCs). With CMS expanding reimbursable procedures in ASCs, startups with ASC-friendly devices (e.g., portable imaging or disposable instruments) are poised to ride a tidal wave.

7. Early Traction with KOLs

Surgeons are the gatekeepers in orthopedics. A startup with early buy-in from key opinion leaders (KOLs)—respected surgeons at top institutions—has a huge leg up. These KOLs can validate the tech, drive adoption, and open doors to hospital systems. I look for startups with advisory boards stacked with credible names and, ideally, pilot studies or early clinical data showing promise. Warning sign: If the startup’s pitch deck is light on surgeon endorsements or clinical feedback, they’re likely too early or disconnected from the market.


The Under-Noticed Gem I’m Watching I won’t name names (yet), but there’s a startup I’ve got my eye on. They’re developing a next-gen fixation system for complex fractures, with a design that cuts OR time by 25% and improves healing rates. The team includes a former Zimmer Biomet exec and a top trauma surgeon. They’re pursuing a 510(k) pathway, leveraging existing reimbursement codes, and have patents pending on their proprietary alloy. Early KOL feedback is stellar, and they’re targeting a $1B market. They’re flying under the radar—no flashy press releases—but their fundamentals scream potential.


Final Thoughts Finding an under-noticed orthopedic startup with breakout potential isn’t about chasing hype. It’s about rigor: a rock-solid team, a must-have product, a clear path to revenue, and a regulatory runway that won’t burn through your capital.

When these pieces align, you’ve got a startup that can go from scrappy to acquired (or IPO’d) in 5-7 years.

more about ​Tiger Scouting​

Let’s have a chat. Pick a time that works for you here – ​http://meetme.so/Tiger​

Keep swinging, Tiger Buford ​tiger@tigerbuford.com​ cell 512-992-9090