I am a small company guy, but cannot ignore the Big Orthos as part of my job, so sharing an overview of the Bigs below.
Based on the latest financial filings for the 2025 fiscal year (reported in early 2026), the orthopedic landscape has seen a complete reshuffling. Stryker has officially taken the lead in pure orthopedic revenue, while major mergers like Globus-NuVasive have created a new "Big Four" in the spine segment.
Here is the 2025 ranking of top orthopedic companies by revenue.
Top Orthopedic Companies by Revenue (Full Year 2025)
Rank
Company
Orthopedic Revenue (2025)
Growth (YoY)
Key Market Focus
1
Stryker
$11.2 Billion
+10.1%*
Knees, Hips, Trauma, & Robotics (Mako)
2
Johnson & Johnson (DePuy Synthes)
$9.2 Billion
+1.1%
Trauma, Spine, and Reconstruction
3
Zimmer Biomet
$7.9 Billion
+3.3%
Hips & Knees (ZBI, ROSA Robotics)
4
Smith+Nephew
$5.8 Billion
+5.7%
Sports Med, Knees, & Hips
5
Medtronic (Cranial & Spine)
$5.0 Billion
+3.6%
Spine implants & Navigation (Stealth)
6
Arthrex
~$3.4 Billion
Estimated
Private leader in Sports Medicine
7
Globus Medical
$2.94 Billion
+16.5%
Spine (combined with NuVasive)
8
Enovis (DJO Global)
$2.27...
