Startup to watch – Loci Orthopaedics.

Pre-clearance, Pre-commercialization, €13.3M raised in 4 rounds so far, located in Ireland.

Website –


We all have a family member who cannot open jars and whose thumb ache day and night. The base of the thumb, the CMC joint,  is the third most common joint affected by arthritis.

1 in 10 people have some degree of thumb base arthritis with many choosing to put up with the discomfort because of limited treatment options.

5% of the world’s population have severe symptoms. This increases to over 30% for women over the age of 55.

There is in excess of 200,000 surgical procedures carried out each year in the EU and US combined for severe thumb base arthritis.


Previous CMC implants designs were wads of autograft tendon (the anchovy procedure), or ceramic balls or other spacers.

The InDx implant is the first implant that can fully mimic the natural but complex motions of the thumb joint.