I met an orthopedic entrepreneur who did every thing right. This Founder/CEO was in the right space at the right time, but missed a business detail. So he failed. Generally right, but specifically wrong. The same Founder/CEO shared a story about a generational relative with a massive farm in Nebraska, strategically positioned along the proposed path of the new transcontinental railway. Anticipating a windfall, the family expanded their land holdings to ensure the railway's passage through their property. Yet, in a surprising twist, the railway planners rerouted the line 30 miles away, bypassing the farm entirely. Generally right, but specifically wrong. For an ortho material example, let's look at Amedica. The founder, AK, introduced silicon nitride into orthopedics, a material with game-changing applications in joint articulation. Amedica was his startup with the ambition to revolutionizing hip replacements with a zero-debris, indestructible ceramic material. Amedica had the makings of a billion-dollar enterprise but was blindsided by an untenable regulatory pathway for articulation applications for hips. Today, the company is rebranded as SINTX, has a valuation of merely $3M....
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