Modifiable polymer promotes a pro-osteogenic, M2-like macrophage phenotype and osteoblastic differentiation of progenitor cells
Joseph G. Bartolaccia,b, Arthi Shridharb, Stephen F. Badylaka-c
McGowan Institute for Regenerative Medicine; b) Bioengineering Department of the University of Pittsbugh; c) Department of Surgery, University of Pittsburgh Medical Center.
Category: Basic Science/Biologics
Keyword: Immunomodulation, Polymer, Macrophage
FDA Device/Drug Status: Approved
Prior/Future Presentation: Yes, 2019, TERMIS Orlando
Abstract Entry:
Background Context:
Poly-ether-ether-ketone (PEEK) has been the most commonly used biomaterial for spinal fusion for many years, primarily because it meets the necessary mechanical requirements to support the pressures to which the spinal column is subjected. However, the biologic response to PEEK has serious limitations including a persistent foreign body response, very modest osseointegration which can result in micromotion, pain, or worse, delamination requiring surgical reintervention. Recent advances in our understanding of immunobiology show that PEEK elicits a proinflammatory phenotype among cells of the innate immune system, inc...
